Melanocortin control of energy balance: evidence from rodent models
نویسندگان
چکیده
منابع مشابه
The central melanocortin system and the regulation of energy balance.
The central melanocortin system is comprised of discrete populations of neurons and circuits that play a key role in maintaining energy balance. This system can sense levels of peripheral energy stores and can integrate a variety of nutrient, neuronal and hormonal signals to regulate food intake, energy expenditure and nutrient metabolism. Disruption of this system at multiple levels causes obe...
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Activation of brain melanocortin-4 receptors (MC4-R) by α-melanocyte-stimulating hormone (MSH) or inhibition by agouti-related protein (AgRP) regulates food intake and energy expenditure and can modulate neuroendocrine responses to changes in energy balance. To examine the effects of AgRP inhibition on energy balance, a small molecule, non-peptide compound, TTP2515, developed by TransTech Pharm...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2011
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-011-0707-5